Abhirami Venkatachalam started her career as a model and won the Miss Tamil Nadu title. In 2016, she starred in the web series Ctrl Alt Delete. The following year, she hosted the reality show Star Wars on Sun TV. Abhirami made her acting debut in Anand Shankar’s NOTA (2018), portraying the love interest of the characters portrayed by senior actors Nassar and Sathyaraj. She then appeared as Kalavu and portrayed one of the leads in the film. That same year, she participated in the third season of the reality show Bigg Boss Tamil. After auditioning for several films, including Kaatru Veliyidai and Vikram Vedha, she landed a role in Nerkonda Paarvai (2019). In a review of the film by The Week, the critic noted that “Abhirami is at her best when she shouts and cries in the courtroom”. She starred in the web series Iru Dhruvam in 2019 with Nandha. She had also auditioned for the lead heroine in Dhruva Natchathiram before she was signed to portray a supporting role. She also signed the Malaysian Tamil film Gajen and an untitled film with Aari Arjuna.